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Ascletis Announces Positive Topline Results of Phase Ib Studies of ASC47 Monotherapy in Australia and U.S. FDA Clearance of IND Application for ASC47 in Combination with Semaglutide
ASC47, an adipose-targeted muscle-preserving weight loss drug candidate for the treatment of obesity, demonstrated a half-life of up to 26 days and 40 days, respectively, in Phase Ib single subcutaneous injection studies in healthy subjects with elevated low-density lipoprotein cholesterol (LDL-C) and patients with obesity, supporting once-monthly to once-bimonthly administration. ASC47 was safe and well tolerated in both healthy subjects with elevated LDL-C and patients with obesity. Previous preclinical data indicated that in a head-to-head diet-induced obese (DIO) mouse model, low dose ASC47 in combination with semaglutide demonstrated a 56.7% greater reduction in body weight compared to semaglutide monotherapy. U.S. Food and Drug Administration (FDA) clearance recognizes and supports a proof-of-concept clinical study of ASC47, an adipose-targeted thyroid hormone receptor beta (THRβ) selective agonist, in combination with an incretin drug. HONG KONG, March 12, 2025 /PRNewswire/ -- Ascletis Pharma Inc. (HKEX:1672, 'Ascletis') announces encouraging pharmacokinetic and weight loss data from its ASC47 Phase Ib single subcutaneous injection studies in Australia in healthy subjects with elevated low-density lipoprotein cholesterol (LDL-C) (Part I) and in patients with obesity (Part II) (NCT06427590).